publication . Article . 2011

Effect of Bile Alcohols on the Microbial 7α-dehydroxylation of Chenodeoxycholic acid

A. Lindqvist; Tore Midtvedt; S. Skrede; Jan Sjövall;
Open Access
  • Published: 01 Jul 2011 Journal: Microbial Ecology in Health & Disease, volume 3 (eissn: 1651-2235, Copyright policy)
  • Publisher: Co-Action Publishing
Abstract
The effect of bile alcohols on the microbial 7α-dehydroxylation of chenodeoxycholic acid was investigated. Bile alcohols isolated from urine of patients with cerebrotendinous xanthomatosis were added to anaerobic incubations of rat faecal microflora or isolated 'Strain II' with [14C]chenodeoxycholic acid, and the formation of labelled metabolites was measured by high-performance liquid chromatography after 7 d of incubation. The 7α-dehydroxylation by rat faecal microflora was inhibited by bile alcohols but not by bile acids. The inhibition started at a concentration of about 0.1 mM and was eight fold at 0-2 mM. In some experiments it was accompanied ...
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Subjects
free text keywords: Cholic acid, chemistry.chemical_compound, chemistry, Cerebrotendinous Xanthomatosis, Biochemistry, Alcohol, Chenodeoxycholic acid, Deoxycholic acid, Incubation, Urine, Bile acid, medicine.drug_class, medicine
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