publication . Article . 2012

Safety evaluation of superheated perfluorocarbon nanodroplets for novel phase change type neurological therapeutic agents

Shimizu, Jun; Endoh, Reiko; Fukuda, Takahiro; Inagaki, Takuya; Hano, Hiroshi; Asami, Rei; Kawabata, Ken-ichi; Yokoyama, Masayuki; Furuhata, Hiroshi;
Open Access English
  • Published: 01 Sep 2012 Journal: Perspectives in Medicine, issue 1-12, pages 25-29 (issn: 2211968X, Copyright policy)
  • Publisher: Elsevier GmbH.
Abstract
Summary Background and purpose Sonothrombolysis using diagnostic ultrasound (US) in combination with microbubble (MB) contrast agents is an attractive trial. Superheated perfluorocarbon nanodroplet (SPN), which can turn into MBs upon US trigger, may have advantages in sonothrombolysis. As a preliminary investigation of SPN-assisted sonothrombolysis, we performed a safety evaluation in vivo. Method Twenty male rabbits (2.59 ± 0.14 kg) were assigned to three groups: the Control group (n = 6), 2.2 mL/kg of physiological saline intravascular (i.v.) injection into auricular vein; the PL group (n = 8), 25 mg/kg of phospholipid-coated SPN i.v.; and the AA group (n = 6)...
Subjects
free text keywords: Perfluorocarbon, Nanodroplets, Microbubble, Sonothrombolysis, Safety, General Medicine, In vivo, Respiration, Neurological Damage, Ultrasound, business.industry, business, Phase change, Pathology, medicine.medical_specialty, medicine, Saline, medicine.medical_treatment, Rectal temperatures, Spleen, medicine.anatomical_structure
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