publication . Article . Other literature type . 2000

Measurements of the dielectric properties of peripheral blood mononuclear cells and trophoblast cells using AC electrokinetic techniques.

Chan, K.L; Morgan, H; Morgan, E; Cameron, I.T; Thomas, M.R;
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  • Published: 01 Mar 2000 Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, volume 1,500, pages 313-322 (issn: 0925-4439, Copyright policy)
  • Publisher: Elsevier BV
Abstract
AbstractThe separation of trophoblast cells from the maternal circulation could provide a valuable diagnostic tool for prenatal diagnosis of genetic abnormalities. This has been attempted using antibody methods, but due to non-specificity of the antibodies, maternal cell contamination remains a problem. We have investigated the potential of dielectrophoretic separation methods as a means of isolating trophoblast cells from mixed peripheral blood mononuclear cells. To determine the potential of this method the dielectric properties of trophoblast cells and mixed peripheral blood mononuclear cells were measured using dielectrophoretic crossover and single cell ele...
Subjects
free text keywords: Molecular Medicine, Molecular Biology, Cell type, Antibody, biology.protein, biology, Peripheral blood mononuclear cell, Electrorotation, Immunology, Trophoblast, medicine.anatomical_structure, medicine, Cell biology, Dielectrophoresis, Membrane potential, Cell, Prenatal diagnosis, Cell separation
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publication . Article . Other literature type . 2000

Measurements of the dielectric properties of peripheral blood mononuclear cells and trophoblast cells using AC electrokinetic techniques.

Chan, K.L; Morgan, H; Morgan, E; Cameron, I.T; Thomas, M.R;