publication . Article . 2006

Fibrillin-1 regulates mesangial cell attachment, spreading, migration and proliferation

Porst, M.; Plank, C.; Bieritz, B.; Konik, E.; Fees, H.; Dötsch, J.; Hilgers, K.F.; Reinhardt, D.P.; Hartner, A.;
Open Access
  • Published: 01 Feb 2006 Journal: Kidney International, volume 69, pages 450-456 (issn: 0085-2538, Copyright policy)
  • Publisher: Elsevier BV
Abstract
The microfibrillar protein fibrillin-1 is present in many organs, including the vasculature, eye, and dermis, and is thought to convey structural anchorage and elastic strength. Fibrillin-1 is also a component of the mesangial matrix. To assess the functional relevance of fibrillin-1 for cell–matrix interactions in the glomerulus, we studied the attachment, spreading, migration and proliferation of mesangial cells on fibrillin-1 and the regulation of fibrillin-1 in experimental anti-Thy1.1 nephritis displaying mesangial cell migration and proliferation in vivo . During the acute phase of experimental Thy1.1 nephritis, glomerular fibrillin-1 messenger ribonucleic...
Subjects
Medical Subject Headings: macromolecular substancesintegumentary systemmusculoskeletal diseasescongenital, hereditary, and neonatal diseases and abnormalitiesskin and connective tissue diseases
free text keywords: Nephrology, Endocrinology, medicine.medical_specialty, medicine, Fibronectin, biology.protein, biology, Cell migration, Cell adhesion, Cell, medicine.anatomical_structure, Internal medicine, Mesangial hypercellularity, Extracellular matrix, Cell growth, Mesangial cell, glomerulus, microfibrillar proteins, proliferation, Thy1.1 nephritis
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