publication . Article . 2011

The Effect of Myosin RLC Phosphorylation in Healthy and Diseased Heart

Priya Muthu; Katarzyna Kazmierczak; Ana Rojas; Yingcai Wang; Theodore Abraham; Danuta Szczesna-Cordary;
Open Access
  • Published: 01 Feb 2011 Journal: Biophysical Journal, volume 100, issue 3 (issn: 0006-3495, Copyright policy)
  • Publisher: Elsevier BV
Abstract
The aim of this study was to understand the mechanism by which the D166V (aspartic acid to valine) mutation in the myosin regulatory light chain (RLC), found to cause hypertrophic cardiomyopathy (HCM) and sudden cardiac death, compromises cardiac contractility and how normal cardiac function could be restored upon phosphorylation of myosin RLC. Our previous studies using papillary muscle fibers from transgenic (Tg) mice expressing the D166V-RLC mutation indicated a diastolic dysfunction caused by a delayed muscle relaxation most likely due to a slower rate of myosin cross-bridge attachment and dissociation. Transmitral Doppler studies confirmed diastolic dysfunc...
Subjects
Medical Subject Headings: macromolecular substances
free text keywords: Biophysics, Biochemistry, Biology, Myofibril, Cardiac function curve, Muscle relaxation, MYH7, Myosin, Myosin light-chain kinase, Cardiac muscle, medicine.anatomical_structure, medicine, Actin
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