publication . Article . 2012

Role of hippocalcin in mediating Aβ toxicity.

Lim Yun-An; Giese Maria; Shepherd Claire; Halliday Glenda; Kobayashi Masaaki; Takamatsu Ken; Staufenbiel Matthias; Eckert Anne; Götz Jürgen;
Open Access English
  • Published: 01 Aug 2012 Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, issue 8, pages 1,247-1,257 (issn: 09254439, Copyright policy)
  • Publisher: Elsevier B.V.
Abstract
Abstract Alzheimer's disease (AD) is the most common cause of dementia, and amyloid-β (Aβ) plaques and tau-containing tangles are its histopathological hallmark lesions. These do not occur at random; rather, the neurodegenerative process is stereotyped in that it is initiated in the entorhinal cortex and hippocampal formation. Interestingly, it is the latter brain area where the calcium-sensing enzyme hippocalcin is highly expressed. Because calcium deregulation is a well-established pathomechanism in AD, we aimed to address the putative role of hippocalcin in human AD brain and transgenic mouse models. We found that hippocalcin levels are increased in human AD ...
Subjects
free text keywords: Alzheimer, Amyloid, Calcium, Pathogenesis, Toxicity, Transgenic mice, Molecular Medicine, Molecular Biology, Neuroprotection, Biology, Hippocalcin, biology.protein, Entorhinal cortex, Genetically modified mouse, Calcium in biology, Biochemistry, Ionomycin, chemistry.chemical_compound, chemistry, Hippocampal formation
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