publication . Article . 2001

Effect of Healing on the Expression of Transforming Growth Factor βs and their Receptors in Chronic Venous Leg Ulcers

Allison J. Cowin; Nicholas Hatzirodos; Christopher A. Holding; Vera Dunaiski; Timothy E. Rayner; Richard H. Harries; Robert Fitridge; Rodney D. Cooter; Gregory S. Schultz; David A. Belford;
Open Access
  • Published: 01 Nov 2001 Journal: Journal of Investigative Dermatology, volume 117, issue 5, pages 1,282-1,289 (issn: 0022-202X, Copyright policy)
  • Publisher: Elsevier BV
Abstract
The transforming growth factor βs are of major importance in the wound repair process; however, no studies to date have investigated the role of the transforming growth factor β receptors in chronic venous leg ulcers or what effect healing has on these proteins. To determine whether the transforming growth factor β peptides and their receptors are expressed in chronic venous wounds, we used immunofluorescent analysis and quantitative competitive reverse transcription polymerase chain reaction to identify the protein and mRNA expression, respectively. Biopsy samples from wounds and normal skin were collected from 12 patients with chronic venous leg ulcers and thr...
Subjects
free text keywords: Cell Biology, Biochemistry, Molecular Biology, Dermatology, healing, immunofluorescence, RT-PCR, wound, Dermis, medicine.anatomical_structure, medicine, Venous leg ulcer, medicine.disease, Receptor, Pathology, medicine.medical_specialty, Transforming growth factor, Growth factor, medicine.medical_treatment, Growth factor receptor, Cytokine, Receptor complex, Biology
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