HIV-1 splicing at the major splice donor site is restricted by RNA structure

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Mueller, Nancy; van Bel, Nikki; Berkhout, Ben; Das, Atze T.;

The 5' leader region of the HIV-1 RNA contains the major 5' splice site (ss) that is used in the production of all spliced viral RNAs. This splice-donor (SD) region can fold a stem-loop structure. We demonstrate that whereas stabilization of this SD hairpin reduces spli... View more
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