publication . Article . 2000

The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular variants of Cd30, Tnfr2, and Cd137

P A Lyons; W W Hancock; P Denny; C J Lord; N J Hill; N Armitage; T Siegmund; J A Todd; M S Phillips; J F Hess; ...
Open Access English
  • Published: 01 Jul 2000 Journal: Immunity, issue 1, pages 107-115 (issn: 10747613, Copyright policy)
  • Publisher: Cell Press. Published by Elsevier Inc.
Abstract
AbstractPrevious analyses of NOD mice have shown that some genes control the development of both insulitis and diabetes, while other loci influence diabetes without reducing insulitis. Evidence for the existence of a gene only influencing diabetes, Idd9 on mouse chromosome 4, is provided here by the development of a novel congenic mouse strain, NOD.B10 Idd9. NOD.B10 Idd9 mice display profound resistance to diabetes even though nearly all develop insulitis. Subcongenic analysis has demonstrated that alleles of at least three B10 genes, Idd9.1, Idd9.2, and Idd9.3 are required to produce Idd9-mediated diabetes resistance. Candidate genes with amino acid differences...
Subjects
free text keywords: Immunology, Biology, Nod, Gene, Candidate gene, Insulitis, medicine.disease, medicine, Genetics, NOD mice, Congenic, Genetic variation, Locus (genetics), Immunology and Allergy, Infectious Diseases
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