publication . Article . 2009

L006 Role of serum response factor (SRF) on microrna expression in the cardiovascular system

Tritsch, E.; Carpentier, W.; Li, Z.; Mericskay, M.;
Open Access
  • Published: 01 Mar 2009 Journal: Archives of Cardiovascular Diseases, volume 102, pages S119-S120 (issn: 1875-2136, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Serum response factor (SRF) is a transcription factor of the MADS box family that regulates essential structural and metabolic genes in many tissues. Using a mouse Cre-Lox model, we have shown previously that SRF inactivation can result in severe cardiac and intestinal failure as well as angiogenic defects. We have performed transcriptomic analyses of gene expression alteration in the cardiac and vascular system following SRF inactivation (see other abstracts) and we found a large number of down-regulated genes but an even larger number that are up-regulated after SRF inactivation. This latter result was partly unexpected since SRF is mainly known as a positive ...
Subjects
Medical Subject Headings: cardiovascular systemgenetic structuresembryonic structures
free text keywords: Cardiology and Cardiovascular Medicine, General Medicine, microRNA, Cell biology, Cardiology, medicine.medical_specialty, medicine, Transcription factor, Internal medicine, Promoter, Transcriptome, Serum response factor, Conditional gene knockout, Transcription (biology), MicroRNA Expression Profile, business.industry, business
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