Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate

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van der Flier, Laurens G; van Gijn, Marielle E; Hatzis, Pantelis; Kujala, Pekka; Haegebarth, Andrea; Stange, Daniel E; Begthel, Harry; van den Born, Maaike; Guryev, Victor; Oving, Irma; van Es, Johan H; Barker, Nick; Peters, Peter J; van de Wetering, Marc; Clevers, Hans;
(2009)
  • Publisher: Elsevier BV
  • Journal: Cell, volume 136, issue 5, pages 903-912 (issn: 0092-8674)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1016/j.cell.2009.01.031
  • Subject: Biochemistry, Genetics and Molecular Biology(all) | Mice, Transgenic | Intestine, Small | Basic Helix-Loop-Helix Transcription Factors | Cell Separation | Animals | Gene Expression Profiling | Mice | Adult Stem Cells | Gene Deletion
    mesheuropmc: digestive system

The small intestinal epithelium is the most rapidly self-renewing tissue of mammals. Proliferative cells are confined to crypts, while differentiated cell types predominantly occupy the villi. We recently demonstrated the existence of a long-lived pool of cycling stem c... View more
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