publication . Article . 2010

Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity.

Schulz, Oliver; Pichlmair, Andreas; Rehwinkel, Jan; Rogers, Neil C.; Scheuner, Donalyn; Kato, Hiroki; Takeuchi, Osamu; Akira, Shizuo; Kaufman, Randal J.; Reis e Sousa, Caetano;
English
  • Published: 01 May 2010 Journal: Cell host and microbe, volume 7, issue 5 (issn: 1931-3128, eissn: 1934-6069, Copyright policy)
  • Country: United Kingdom
Abstract
Cytosolic viral RNA recognition by the helicases RIG-I and MDA5 is considered the major pathway for IFN-alpha/beta induction in response to RNA viruses. However, other cytoplasmic RNA sensors, including the double-stranded RNA-binding protein kinase R (PKR), have been implicated in IFN-alpha/beta production, although their relative contribution and mechanism have been unclear. Using cells expressing nonfunctional PKR or reduced levels of kinase, we show that PKR is required for production of IFN-alpha/beta proteins in response to a subset of RNA viruses including encephalomyocarditis, Theiler's murine encephalomyelitis, and Semliki Forest virus, but not influenz...
Subjects
Medical Subject Headings: virusesvirus diseasesbiochemical phenomena, metabolism, and nutrition
free text keywords: Microbiology, Parasitology, Virology, EIF-2 kinase, biology.protein, biology, Protein kinase R, RNA, Sendai virus, biology.organism_classification, Messenger RNA, Orthomyxoviridae, Molecular biology, Immunology, MDA5, Interferon, medicine.drug, medicine, Immunology and Microbiology(all), Cancer Research, MICROBIO, MOLIMMUNO
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