publication . Article . 2013

Extrinsic Noise Enhances Switching in Models of Cellular Decision Making

Roberts, Elijah; Assaf, Michael;
Open Access English
  • Published: 01 Jan 2013 Journal: Biophysical Journal, issue 2, page 160a (issn: 00063495, Copyright policy)
  • Publisher: Biophysical Society. Published by Elsevier Inc.
Abstract
Numerous biological processes do not follow deterministic rules, i.e., genetically identical cells can display different phenotypes even in identical environments. Such processes involve what is termed cellular decision making, where individual cells probabilistically make choices that determine their fate. One view of cellular decision making is that stochastic noise present in the biomolecular interaction networks responsible for the decisions is a major factor in their probabilistic nature. Most previous work has been focused on the intrinsic noise of these networks, but, especially for high copy-number biomolecules, extrinsic noise is likely much more signif...
Subjects
free text keywords: Biophysics, Adiabatic process, Biology, Dynamical system, Fixed point, Statistical physics, Switching time, Bistability, White noise, Probabilistic logic, Crystallography, Parameter space
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