publication . Article . 2010

Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients.

Komaba, Hirotaka; Goto, Shunsuke; Fujii, Hideki; Hamada, Yasuhiro; Kobayashi, Akira; Shibuya, Koji; Tominaga, Yoshihiro; Otsuki, Naoki; Nibu, Ken-ichi; Nakagawa, Kimie; ...
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  • Published: 01 Feb 2010 Journal: Kidney International, volume 77, pages 232-238 (issn: 0085-2538, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Fibroblast growth factor 23 (FGF23) exerts its effect by binding to its cognate FGF receptor 1 (FGFR1) in the presence of its co-receptor Klotho. Parathyroid glands express both FGFR1 and Klotho, and FGF23 decreases parathyroid hormone gene expression and hormone secretion directly. In uremic patients with secondary hyperparathyroidism (SHPT), however, parathyroid hormone secretion remains elevated despite extremely high FGF23 levels. To determine the mechanism of this resistance, we measured the expression of Klotho, FGFR1, and the proliferative marker Ki67 in 7 normal and 80 hyperplastic parathyroid glands from uremic patients by immunohistochemistry. All urem...
Subjects
Medical Subject Headings: stomatognathic diseasesurologic and male genital diseases
free text keywords: Nephrology, Parathyroid hormone secretion, Hormone, Hyperplasia, medicine.disease, medicine, Secondary hyperparathyroidism, Endocrinology, medicine.medical_specialty, Fibroblast growth factor receptor 1, Fibroblast growth factor 23, Pathogenesis, Klotho, Internal medicine, business.industry, business, chronic kidney disease, FGF23, FGFR1, parathyroid
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