publication . Article . Other literature type . 2014

A Hierarchical Map of Regulatory Genetic Interactions in Membrane Trafficking

Liberali Prisca; Snijder Berend; Pelkmans Lucas;
  • Published: 01 Jun 2014
Abstract
Summary Endocytosis is critical for cellular physiology and thus is highly regulated. To identify regulatory interactions controlling the endocytic membrane system, we conducted 13 RNAi screens on multiple endocytic activities and their downstream organelles. Combined with image analysis of thousands of single cells per perturbation and their cell-to-cell variability, this created a high-quality and cross-comparable quantitative data set. Unbiased analysis revealed emergent properties of the endocytic membrane system and how its complexity evolved and distinct programs of regulatory control that coregulate specific subsets of endocytic uptake routes and organell...
Subjects
free text keywords: General Biochemistry, Genetics and Molecular Biology, RNA interference, Endocytosis, Cell biology, Cell physiology, Membrane, Endocytic cycle, Organelle, Cytoskeleton, Biology, Biochemistry, Genetics and Molecular Biology(all)
Related Organizations
Funded by
SNSF| Functional network analysis of the host-virus interactome
Project
  • Funder: Swiss National Science Foundation (SNSF)
  • Project Code: P300P3_147897
  • Funding stream: Careers;Fellowships | Advanced Postdoc.Mobility
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