publication . Article . 1999

Effect of proteinuria reduction on prevention of focal glomerulosclerosis by angiotensin-converting enzyme inhibition is modifiable

Eric De Boer; Gerjan Navis; Frits-Hein Wapstra; Paul E. De Jong; Dick De Zeeuw;
Open Access English
  • Published: 01 Jul 1999 Journal: Kidney International (issn: 00852538, Copyright policy)
  • Publisher: International Society of Nephrology. Published by Elsevier Inc.
Abstract
Effect of proteinuria reduction on prevention of focal glomeru-losclerosis by ACE inhibition is modifiable. Background Proteinuria is associated with a progressive loss of renal function; we recently found that both intrarenal effects of proteinuria and the state of systemic nephrosis play an independent role in proteinuria-induced renal damage. Reduction of proteinuria is an important mechanism underlying the renoprotective effect of angiotensin-converting enzyme inhibition (ACEi). Both the reduction of proteinuria and the attenuation of the systemic state of nephrosis may be involved in the renoprotection by ACEi. Methods This article entails a post hoc analys...
Subjects
Medical Subject Headings: urologic and male genital diseases
free text keywords: glomerulosclerosis, cholesterol, adriamycin nephrosis, sodium restriction, lisinopril, RENAL-DISEASE, GLOMERULAR INJURY, ACE-INHIBITION, RATS, AMINONUCLEOSIDE, ABLATION, UMCG Approved, Nephrology, Nephrosis, medicine.disease, medicine, Proteinuria, medicine.symptom, Endocrinology, medicine.medical_specialty, Internal medicine, medicine.drug, Angiotensin-converting enzyme, biology.protein, biology, Nephrotic syndrome, Renal function, Nephropathy, business.industry, business
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