ANTIVIRAL ACTIVITY OF CYCLOPENTANE β,β'-TRI¬KETONES RELATED TO SECONDARY METABOLITES OF HIGHER PLANTS

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Лапшина, Лариса Анатольевна ; Шестак, Ольга Петровна ; Реунов, Анатолий Васильевич ; Новиков, Вячеслав Леонидович (2013)
  • Publisher: Altai State University
  • Journal: Khimiia rastitel'nogo syr'ia (Chemistry of plant raw material) (issn: 1029-5143, eissn: 1029-5151)
  • Related identifiers: doi: 10.14258/jcprm.1302107
  • Subject: cyclopentane β,β'-triketones, sodium salts of cyclopentane β,β'-triketones, antiviral activity, tobacco mosaic virus, leaves of Nicotiana tabacum L. cv. Xanthi-nc | циклопентановые β,β'-трикетоны, натриевые соли циклопентановых β,β'-трикетонов, антивирусная активность, вирус табачной мозаики, табак сорта Ксанти-нк

Effects of twenty synthetic cyclopentane β,β'-triketones and their sodium salts on development of the infection caused by tobacco mosaic virus (TMV) in the leaves of Nicotiana tabacum L. cv. Xanthi-nc were studied. It was shown that the most antiviral effect exibit Na-salts of 2-acetyl-4,7-dithia-2,3,4,5,6,7-hexahydro-1H-indene-1,3-dione, 2-acetyl-4-oxa-7-thio-2,3,4,5,6,7-hexahydro-1H-indene-1,3-dione and 2-acetyl-4,5-didodecylthiacyclopent-4-ene-1,3-dione. Inoculation of Xanthi-nc leaves with TMV mixed with Na-salts of these compounds (2 mg/ml) resulted in a significant decrease (98%) in the number of local lesions as compared to leaves inoculated with TMV alone. Leaves treated with these salts at a concentration of 2 mg/ml did not show any toxic symptoms.
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