MOLECULAR COMPLEXES OF IVY AND LICORICE SAPONINS WITH SILDENAFIL CITRATE (VIAGRA) AND ITS BIOLOGICAL ACTIVITY

Article Russian OPEN
Яковишин, Леонид Александрович ; Лекарь, Анна Владимировна ; Ветрова, Елена Владимировна ; Борисенко, Николай Иванович ; Борисенко, Сергей Николаевич ; Гришковец, Владимир Иванович (2013)
  • Publisher: Altai State University
  • Journal: Khimiia rastitel'nogo syr'ia (Chemistry of plant raw material) (issn: 1029-5143, eissn: 1029-5151)
  • Related identifiers: doi: 10.14258/jcprm.1303099
  • Subject: triterpene glycosides, -hederin, hederasaponin C, glycyram, sildenafil citrate, molecular complex, mass spectroscopy, ichthyotoxicity, allelopathic activity | тритерпеновые гликозиды, -хедерин, хедерасапонин С, глицирам, цитрат силденафила, молекулярный комплекс, масс-спектроскопия, ихтиотоксичность, аллелопатическая активность

The molecular complexation of triterpene glycosides a-hederin (hederagenin 3-O-a-L-rhamnopyranosyl-(1®2)-O-a-L-arabinopyranoside), hederasaponin C (hederagenin 3-O-a-L-rhamnopyranosyl-(1®2)-O-a-L-arabinopyranosyl-28-О-a-L-rhamnopyranosyl-(1®4)-О-b-D-glucopyranosyl-(1®6)-О-b-D-glucopyranoside) and glycyram (monoammonium glycyrrhizinate) with sildenafil citrate was investigated for the first time using the electrospray ionization mass spectroscopy. The glycosides form complex in the 1:1 molar ratio. The influence of complex on Avena sativa seeds germination and its ichthyotoxicity against Poecilia reticulata were studied.
Share - Bookmark