EFFECT OF 1,5-BIS(3,5-DIMETHYLPYRAZOL-1-YL)-3-OXAPENTANE DIACETATOCOPPER ON THE RATS

Article Russian OPEN
Nofal, A. E. ; Ovcharenko, N. D. (2016)
  • Publisher: Altai State University, Biological Faculty
  • Journal: Acta Biologica Sibirica (issn: 2412-1908, eissn: 2412-1908)
  • Related identifiers: doi: 10.14258/abs.v2i2.1344
  • Subject: Biology; Zoology; Animal Physiology | effect; hypoglycemic; antilipolytic; toxic; glucose; glycogen; free fatty acids; albumin; liver enzymes. | Биология; Зоология; Физиология животных | эффект; гипогликемический; антилиполитический; токсический; глюкоза; гликоген; свободные жирные кислоты; альбумин; печеночные ферменты.

A lot of pyrazole derivatives exhibit various pharmacological properties and are characterized by an antioxidant, antiviral activity, anti-inflammatory, immunomodulating properties, as well as antidepressive and anti-tumor effect. This work is based on the results of morphometric parameters of the body and liver weight as well as biochemical analysis of blood of healthy adult male albino rats following a single and multiple intraperitoneal administration of 1,5-Bis(3,5-dimethylpyrazol-1-yl)-3-oxapentane diacetatocopper dissolved in a freshly prepared physiological saline solution (dose 12 mg / kg body weight). The results of research showed that, the administration of drug to rats exhibit various effects. It is established that the research substance has hypoglycemic effect evidenced by decreasing glucose level in the blood and increasing the amount of glycogen in the liver. It has also, antilipolytic effect which is confirmed by decreasing free fatty acids levels in the blood. Moreover, it's toxic effect is manifested by rising levels of liver enzymes alanine aminotransferase and aspartate aminotransferase as well as reducing albumin levels in the blood serum and the decrease in the body and liver weight. These effects are saved only after repeated daily administration of the drug for 6 weeks.
Share - Bookmark