ВЛИЯНИЕ 1,5-БИС(3,5-ДИМЕТИЛПИРАЗОЛ-1-ИЛ)-3-ОКСАПЕНТАН-ДИАЦЕТАТОМЕДИ НА СТРУКТУРНО-ФУНКЦИОНАЛЬНЫЕ ПОКАЗАТЕЛИ ПЕЧЕНИ И ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ КРЫС В УСЛОВИЯХ ЭКСПЕРИМЕНТА

Article Russian OPEN
Nofal, A. E. ; Ovcharenko, N. D. (2016)
  • Publisher: Altai State University, Biological Faculty
  • Journal: Acta Biologica Sibirica (issn: 2412-1908, eissn: 2412-1908)
  • Related identifiers: doi: 10.14258/abs.v2i2.1346
  • Subject: Agriculture | кариопикноз | Biology; Zoology; Animal Physiology | кровотечения | S | infiltration; hemorrhage; karyopyknosis; karyorrhexis; karyolysis; total protein | Биология; Зоология; Физиология животных | инфильтрация | общий белок | кариорексис | кариолизис | инфильтрация; кровотечения; кариопикноз; кариорексис; кариолизис; общий белок

Various factors including chemical substances affecting on the human and animal organisms, causing a series of changes in the structural and metabolic processes. Chemical compounds cause a violation in the homeostatic regulatory systems, liver function and also influences the metabolism of hormones produced by the gonads in experimental animals. These studies suggest that, the intraperitoneal administration rats by 1,5-Bis(3,5-dimethylpyrazol-1-yl)-3-oxapentane diacetatocopper (dose 12 mg per kg of body weight for 6 weeks) led to disturbance of the normal structure of the liver and pancreas. This drug caused intensively neutrophilic infiltration around venous vessels with bleeding, endoplasmic vacuolation of most cells, karyopyknosis, karyorrhexis, and karyolysis, as well as, increasing the amount of binucleated cells. This treatment led to a reduction in the total protein content in the tissue of liver and pancreas, as well as activation of the apoptotic process in liver cells.
  • References (17)
    17 references, page 1 of 2

    Bergamini E, De Tata, V, Cubeddu, T.L., Masiello, P., Pollera, M. (1987). Increased degradation in rat liver induced by antilipolytic agents: A model for studying autophagy and protein degradation in Liver. Exp. and Mol. Pathol., 46, 114 -122.

    Donatia, A., Ventruria, A., Cavallinia, G., Masini, M., Vittorini, S., Chantret, I., Codogno, P., Bergamini, E. (2008). In vivo effect of an antilipolytic drug (3,5-dimethylpyrazole) on autophagic proteolysis and autophagy-related gene expression in rat liver. Biochem. and Biophys. Res. Commun., 366, 786-792.

    Guo, L., Xiao, S., Gou, Y. (2004). Detection of bcl-2 and bax expression and bcl-2/JH fusion gene in intrahepatic cholangiocarcinoma. World J. Gastroenterol., 10(22), 3251-3254.

    Hockenbery, D.M., Zutter, M., Hickey, W. (1991). Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc. Nat. Acad. Sci., 88, 6961-6965.

    Korsmeyer, S.J. (1992). Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood., 80, 879- 886.

    Lillie, R.D., Fulmer, H.M. (1976). Histopathological Technique and Practical Histochemistry. New York: Mc Graw Hill.

    Locci, C.T., Masiello, P., Pollera, M. (1985). Effects of antilipolytic agents on rat liver peroxisomes and peroxisomai oxidative activities. Biochim. and Biophys. Acta, 839, 96-104.

    Lu, Y., Cederbaum, A.I. (2006). Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P450 2E1 and 2A5. Hepatol., 44(1), 263-274.

    Ovsyanko, E.V., Lushnikova, E.L., Larionov, P.M. (2009). Immunohistochemical study for the expression of Bcl-2 family proteins in Walker 256 carcinosarcoma cells under the influence of cytostatic drugs. Bull. Exp. Biol. Med., 148(4), 650-655.

    Pearse, A.G.E. (1972). Histochemistry, Theoretical and Applied. London: Churchill Livingstone.

  • Metrics
    No metrics available
Share - Bookmark