STUDY OF AERIAL PARTS OF GLYCYRRHIZA GLABRA AS PROMISING RAW MATERIALS FOR THE PRODUC-TION OF DRUGS

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Маматханова (Mamatkhanova), Мунирахон (Munirahon) Ахматхановна (Ahmathanovna) ; Абдурахманов (Abdurakhmanov), Бахтияр (Bahtijar) Алимович (Alimovich) ; Нигматуллаев (Nigmatullaev), Бахтияр (Bahtijar) Алимович (Alimovich) ; Сотимов (Sotimov), Гайрат (Gajrat) Бахтиёривич (Bahtijorivich) ; Халилов (Khalilov), Равшанжон (Ravshanzhon) Муратджанович (Muratdzhanovich) ; Маматханов (Мамаtkhanov), Ахмадхон (Ahmadhon) Умарханович (Umarhanovich) (2016)
  • Publisher: Altai State University
  • Journal: Khimiia rastitel'nogo syr'ia (Chemistry of plant raw material) (issn: 1029-5143, eissn: 1029-5151)
  • Related identifiers: doi: 10.14258/jcprm.201601685
  • Subject: licorice, aerial part, Glycyrrhiza glabra, raw material, flavonoids, anti-inflammatory preparation, «Glatsembrin», pinocembrin, spectrophotometric method, The Republic of Karakalpakstan | солодка голая, надземная часть, Glycyrrhiza glabra, сырье, сумма флавоноидов, препарат противовоспалительного дей-ствия, глацембрин, пиноцембрин, спектрофотометрический метод, Республика Каракалпакстан

New anti-inflammatory preparation «Glatsembrin» was developed on the basis of the sum of flavonoids of the aerial part of licorice (Glycyrrhiza glabra). Assessment of the quality of the aerial part of licorice had been to make by the content of total flavonoids. During the qualitative reaction of the extraction from raw materials with a solution of ferric chloride brownish-green colour was appeared, which indicates the presence of compounds of phenolic nature. A spectrophotometric method for quantitative determination of total flavonoids converting to pinocembrin was developed. The content of flavonoids in the raw material was not less than 1,0%. The content of flavonoids in the aerial part of licorice at various vegetation periods collected from different places of growth was identified. Our data suggest that the raw material should be collected during the period of mass flowering (in the second half of May). Relative error of the proposed method is 6,47%. The changes of the content of total flavonoids after time in the aerial part of licorice were studied and it was found that the raw material is kept stable for two years. Arrays thickets of licorice in Uzbekistan were defined. It was founded that the largest area of commercial arrays of licorice more than 15,000 hectares locates in the Republic of Karakalpakstan. 
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