NEW PROSPECTIVE HERBAL SOURCE OF D-PINITOLA POSSESSING ANTI-DIABETIC AND HYPOGLYCEMIC PROPERTIES

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Альмагамбетов (Al'magambetov), Алибек (Alibek) Муратович (Muratovich) ; Темиргазиев (Temirgaziev), Бахтияр (Bakhtiiar) Серикович (Serikovich) ; Заварзин (Zavarzin), Игорь (Igor') Викторович (Viktorovich) ; Качала (Kachala), Вадим (Vadim) Вадимович (Vadimovich) ; Кудабаева (Kudabaeva), Перизат (Perizat) Какеновна (Kakenovna) ; Тулеуов (Tuleuov), Бораш (Borash) Игликович (Iglikovich) ; Адекенов (Adekenov), Сергазы (Sergazy) Мынжасарович (Mynzhasarovich) (2016)
  • Publisher: Altai State University
  • Journal: Khimiia rastitel'nogo syr'ia (Chemistry of plant raw material) (issn: 1029-5143)
  • Related identifiers: doi: 10.14258/jcprm.2016031004
  • Subject: Silene brahuica Boiss; isobutanol extract; high-performance liquid chromatography; D-pinitol; phytoecdysteroids; ecdysterone | Silene brahuica Boiss; изобутанольный экстракт; высокоэффективная жидкостная хроматография; D-пинитол; фитоэкдистероиды; экдистерон

It is earlier established that phytoecdysteroids – important secondary metabolites of plants, for the first time in the genus Silene L. – Silene of Caryophyllaceae Juss family. (Caryophyllaceae) were found in plants of Silene praemixta M.Pop., then in Silene brahuica Boiss.In the submitted article we carried out complex studying of a chemical profile of Silene brahuica Boiss., which is collected in the Southern region of Kazakhstan in natural habitats and is respectively prospective industrial and available source of the above mentioned important products of the secondary exchange of plants.The purpose of work was phytochemical research of elevated part of Silene brahuica Boiss. on the accompanying biologically active agents which are present in plant, with use of the HPLC method and columnar chromatography.It is established that at aqueous ethanol, and then isobutanol extraction the main components are phytoecdysteroids and for the first time cyclic polyol isolated with a quantitative exit from this plant. The thin structure of D-pinitola (1S,2S,4S,5R)-6- methoxycyclohexane-1,2,3,4,5-pentol), possessing anti-diabetic and hypoglycemic properties are characterized with use of NMR1H, 13C (HSQC, COSY, NOESY) – spectroscopy.
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