EVALUATION OF ANTIOXIDANT ACTIVITY OF COMPLEXES OF DIHYDROQUERCETIN WITH BIOGENIC METALS IONS

Article Russian OPEN
Столповская (Stolpovskaia), Елена (Elena) Владимировна (Vladimirovna) ; Трофимова (Trofimova), Наталья (Natal'ia) Николаевна (Nikolaevna) ; Бабкин (Babkin), Василий (Vasilii) Анатольевич (Anatol'evich) (2016)
  • Publisher: Altai State University
  • Journal: Khimiia rastitel'nogo syr'ia (Chemistry of plant raw material) (issn: 1029-5143, eissn: 1029-5151)
  • Related identifiers: doi: 10.14258/jcprm.2016041402
  • Subject: dihydroquercetin; complex compounds; antioxidant activity; malondialdehyde; diene and triene conjugates; catalase | дигидрокверцетин; комплексные соединения; антиоксидантная активность; малоновый диальдегид; диеновые и триеновые конъюгаты; каталаза

The antioxidant activity of complexes of dihydroquercetin (DHQ) with ions Zn2+, Cu2+ and Ca2+ have been investigated in experiments in vitro with blood plasma of healthy donors. The state of the lipid peroxidation (LPO) in blood plasma have been evaluated on the content of malondialdehyde (MDA), diene (DC) and triene (TC) conjugates. The impact of the complexes and DHQ on the enzyme catalase activity in blood plasma have been determined. It is found that complex of DHQ with zinc ion reduces the content of MDA in blood plasma of 14,9% compared with the control. This exceeds twice the significant for DHQ (7,5%). The corresponding figures for complexes of DHQ with ions of copper (II) and calcium are amount to 11,2 and 3,7%. Effect of complexes to decrease of DC and TC in blood plasma compared with control is comparable with the corresponding values for DHQ. Complex of DHQ with zinc ion increases catalase activity by 1,5% compared to DHQ. Complexes of DHQ with ions copper (II) and calcium increases catalase activity by no more than DHQ.
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