MASS SPECTROMETRIC STUDY OF MOLECULES SELF-ASSEMBLY OF GLYCYRRHETINIC ACID

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Борисенко (Borisenko), Сергей (Sergej) Николаевич (Nikolaevich) ; Лекарь (Lekar’), Анна (Anna) Владимировна (Vladimirovna) ; Ветрова (Vetrova), Елена (Elena) Владимировна (Vladimirovna) ; Филонова (Filonova), Ольга (Ol'ga) Владимировна (Vladimirovna) ; Борисенко (Borisenko), Николай (Nikolaj) Иванович (Ivanovich) (2015)
  • Publisher: Altai State University
  • Journal: Khimiia rastitel'nogo syr'ia (Chemistry of plant raw material) (issn: 1029-5143, eissn: 1029-5151)
  • Related identifiers: doi: 10.14258/jcprm.201501229
  • Subject: self-association, glycyrrhetinic acid, glycyrrhizic acid, mass spectrometry with electrospray ionization, supramolecular complexes | самоассоциация; глицирретиновая кислота; глицирризиновая кислота; масс-спектрометрия; ионизация электрораспылением; комплексообразование; супрамолекулярные комплексы

Mass spectrometrywith the electrospray ionizationwas used to studythe processes of self-association of glycyrrhetinicacid, which is the aglycone of glycyrrhizic acid. It was shown that stereoisomers of glycyrrhetinicacidcan form self-associates by analogywithtriterpenesaponinswith the free carboxylgroups.The ability glycyrrhetinic acid to form self-associates was registered in the mass spectra. It has been established that the ionization of associates GLA to form the anion occurs quite weak. At the same time, GLA ionization in the positive ion mode occurs efficiently and allows registering multidimensional structures 1 to 8 molecules of 18α-GLA and 1 to 9 molecules of 18β-GLA. The most comprehensive structure of associates GLA is presented in the mass spectra of positive ions. The resultsdemonstrated the ability of18α- and18β-GLA to formself-associates, and highpotential of GLA to formsupramolecular complexes. Stereoisomers ofglycyrrhetinicaslicoricesaponinsmaybe a basis for thesynthesisof a new generationof non-covalentmolecular complexesandnew highlymedicinal substancesfor both improvementof bioavailability.
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