publication . Article . 2016

Synthesis, Degradation, Biocompatibility and Drug Release Studies of Bis 2-Hydroxy Ethyl Terephthalate-based Poly(Mannitol-Citric-Sebacate) Ester

Athira K Sunil; Sarkar K; Kaushik Chatterjee;
Open Access English
  • Published: 20 Jun 2016 Journal: Journal of Modern Materials (issn: 2456-4834, eissn: 2456-4834, Copyright policy)
  • Publisher: AIJR Publisher
Abstract
<jats:p>Bis 2-Hydroxy Ethyl Terephthalate-based biodegradable poly(mannitol-citric-sebacate) has been synthesized by catalyst-free melt condensation process using two different diacids and Bis 2-Hydroxy Ethyl Terephthalate with D-mannitol as monomers having a potential to be metabolized in vivo. The biocompatibility of the polymer, Bis 2-Hydroxy Ethyl Terephthalate-poly(mannitol-citric-sebacate) has been tested using human primary stromal cells. In vitro degradation of Bis 2-Hydroxy Ethyl Terephthalate-poly(mannitol-citric-sebacate) polymer in Phosphate Buffered Saline solution carried out at physiological conditions indicates that the degradation goes to comple...
Subjects
free text keywords: Drug carrier, Biodegradable polymer, Biocompatibility, Drug delivery, Materials science, Monomer, chemistry.chemical_compound, chemistry, Polymer chemistry, Polymer, chemistry.chemical_classification, In vivo, Mannitol, medicine.drug, medicine
Related Organizations
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publication . Article . 2016

Synthesis, Degradation, Biocompatibility and Drug Release Studies of Bis 2-Hydroxy Ethyl Terephthalate-based Poly(Mannitol-Citric-Sebacate) Ester

Athira K Sunil; Sarkar K; Kaushik Chatterjee;