publication . Article . 2018

Toll-like Receptors Regulate MIF Expression in Benign Lymphoepithelial Lesion of the Lacrimal Gland

Mawulikplimi Yao Adzavon; Pengxiang Zhao; Xujuan Zhang; Xin Zhang; Limin Wang; Tarekegn Gebreyesus Abisso; Xuemei Ma;
Open Access English
  • Published: 30 Mar 2018 Journal: International Annals of Science (issn: 2456-7132, eissn: 2456-7132, Copyright policy)
  • Publisher: AIJR Publisher
Abstract
<jats:p>Despite a perpetual increase in the prevalence of benign lymphoepithelial lesion, data on the mechanisms governing its pathogenesis are still missing. Thus, we aimed in the present study to evaluate whether TLRs could regulate the expression of the pleiotropic pro-inflammatory and tumor-related cytokine MIF in BLEL. Using gene expression profiling and protein expression analysis methods, we found that TLRs were overexpressed and that their signaling pathways were activated in BLEL. We have also confirmed in tissues biopsies, the overexpression of MIF reported previously in plasma of BLEL specimen. The analysis of the TLR7/8 impact on the expression of MI...
Subjects
free text keywords: Cytokine, medicine.medical_treatment, medicine, TLR7, Cell, medicine.anatomical_structure, Benign lymphoepithelial lesion, medicine.disease, Gene expression profiling, Signal transduction, Cancer research, Macrophage migration inhibitory factor, Receptor, Biology
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publication . Article . 2018

Toll-like Receptors Regulate MIF Expression in Benign Lymphoepithelial Lesion of the Lacrimal Gland

Mawulikplimi Yao Adzavon; Pengxiang Zhao; Xujuan Zhang; Xin Zhang; Limin Wang; Tarekegn Gebreyesus Abisso; Xuemei Ma;