project . 2017 - 2022 . On going

Regulation of B cell activation and differentiation by AU-rich element RNA binding proteins

Wellcome Trust
  • Funder: Wellcome TrustProject code: 200823
  • Funded under: Immune System in Health and Disease Funder Contribution: 1,245,380 GBP
  • Status: On going
  • Start Date
    01 Apr 2017
    End Date
    01 Apr 2022
Description
My proposal will test the hypothesis that B lymphocyte activation and differentiation is regulated by a subset of sequence-specific RNA Binding Proteins (RBP) encoded by the zfp36 family of genes. The main questions are: 1. What is the role of the zfp36 genes in B cell activation, selection and terminal differentiation? 2. What processes do these RBP regulate at the cellular level in activated B cells? 1. Which post-transcriptional steps are regulated by the RBP? 2. How do the zfp36 family genes function in normal and malignant human B cells? The dynamic regulation of the transcriptome is an indispensable feature of B lymphocyte function that is frequently dysre...
Description
My proposal will test the hypothesis that B lymphocyte activation and differentiation is regulated by a subset of sequence-specific RNA Binding Proteins (RBP) encoded by the zfp36 family of genes. The main questions are: 1. What is the role of the zfp36 genes in B cell activation, selection and terminal differentiation? 2. What processes do these RBP regulate at the cellular level in activated B cells? 1. Which post-transcriptional steps are regulated by the RBP? 2. How do the zfp36 family genes function in normal and malignant human B cells? The dynamic regulation of the transcriptome is an indispensable feature of B lymphocyte function that is frequently dysre...
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