project . 2020 - 2025 . On going

Analyses of paired host-virus genomic data to understand disease heterogeneity of chronic viral infections.

Wellcome Trust
  • Funder: Wellcome TrustProject code: 220171
  • Funded under: Genetics, Genomics and Population Research Funder Contribution: 1,153,490 GBP
  • Status: On going
  • Start Date
    01 May 2020
    End Date
    01 May 2025
Description
Host and pathogen genetic variations are major causes of clinical outcomes of infectious diseases. Traditionally, genetic studies of infectious diseases have sought to explain between-individual variation in disease by assessing genetic factors separately in humans or pathogens, under the assumption that these factors are independent. However, there is strong theoretical evidence that genetic interactions between host and viruses play a major role in viral disease aetiology. The major limiting factor to date has been the lack of cohorts with paired host-virus data. Recent technological developments and reductions in the cost of high-throughput viral sequencing f...
Description
Host and pathogen genetic variations are major causes of clinical outcomes of infectious diseases. Traditionally, genetic studies of infectious diseases have sought to explain between-individual variation in disease by assessing genetic factors separately in humans or pathogens, under the assumption that these factors are independent. However, there is strong theoretical evidence that genetic interactions between host and viruses play a major role in viral disease aetiology. The major limiting factor to date has been the lack of cohorts with paired host-virus data. Recent technological developments and reductions in the cost of high-throughput viral sequencing f...
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