project . 2018 - 2021 . On going

Neuromodulation of death in Caenorhabditis elegans

Wellcome Trust
  • Funder: Wellcome TrustProject code: 214076
  • Funded under: Physiology in Health and Disease Funder Contribution: 99,933 GBP
  • Status: On going
  • Start Date
    18 Nov 2018
    End Date
    17 Mar 2021
Description
The Nobel Prize-awarded discovery of programmed cell death while studying Caenorhabditis elegans nematode cell lineage revolutionised biomedicine. Although pervasive across living organisms and despite incredible potential applications, organismal death remains understudied, partly due to the lack of reliable death-markers. In nematode worms, death is marked by an impressive blue fluorescence burst, allowing us to study events that immediately precede death. Using this marker, we found that alteration of conserved neuromuscular pathways can delay worm death. Death fluorescence, whole-brain imaging at single-cell resolution, and a transparent model organism with ...
Description
The Nobel Prize-awarded discovery of programmed cell death while studying Caenorhabditis elegans nematode cell lineage revolutionised biomedicine. Although pervasive across living organisms and despite incredible potential applications, organismal death remains understudied, partly due to the lack of reliable death-markers. In nematode worms, death is marked by an impressive blue fluorescence burst, allowing us to study events that immediately precede death. Using this marker, we found that alteration of conserved neuromuscular pathways can delay worm death. Death fluorescence, whole-brain imaging at single-cell resolution, and a transparent model organism with ...
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