project . 2016 - 2026 . On going

Nuclear RNA processing and surveillance

Wellcome Trust
  • Funder: Wellcome TrustProject code: 109916
  • Funded under: Molecular Basis of Cell Function Funder Contribution: 5,167,430 GBP
  • Status: On going
  • Start Date
    01 Oct 2016
    End Date
    30 Sep 2026
Description
All eukaryotic RNAs are substrates for nuclear RNA processing and quality control systems. These are generally well conserved between yeast and humans but, despite their ubiquity and importance, key features remain unclear. We will address these using newly developed techniques, initially with genome-wide analyses and then focusing on specific interactions to determine the functional significance of general features and correlations. Numerous long non-protein-coding RNAs (lncRNAs) are transc ribed in yeast and other eukaryotes. We will test the hypothesis that distinct mRNA and lncRNA fates are conferred cotranscriptionally and determine what gene features under...
Description
All eukaryotic RNAs are substrates for nuclear RNA processing and quality control systems. These are generally well conserved between yeast and humans but, despite their ubiquity and importance, key features remain unclear. We will address these using newly developed techniques, initially with genome-wide analyses and then focusing on specific interactions to determine the functional significance of general features and correlations. Numerous long non-protein-coding RNAs (lncRNAs) are transc ribed in yeast and other eukaryotes. We will test the hypothesis that distinct mRNA and lncRNA fates are conferred cotranscriptionally and determine what gene features under...
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