project . 2021 - 2025 . On going

Impact of autophagy on lymphocyte stemness

Wellcome Trust
  • Funder: Wellcome TrustProject code: 220452
  • Funded under: Immune System in Health and Disease Funder Contribution: 300,000 GBP
  • Status: On going
  • Start Date
    01 Apr 2021
    End Date
    31 Mar 2025
Description
Efficient T cell responses rely on heterogeneity, characterized by the rise of effector and memory cells. Autophagy, responsible for homeostatic degradation and recycling of cell cargo, is crucial for T cell differentiation. Upon ageing, autophagy is impaired, which is detrimental for the generation of memory cells retaining stemness. Interestingly, I have observed that naïve CD8+ T cells from aged mice are unable to undergo asymmetric cell division (ACD) (unpublished). ACD is a conserved mechanism to generate diversity, by endowing daughter cells with different fate determinants. As both autophagy and ACD are involved in T cell differentiation and impaired upon...
Description
Efficient T cell responses rely on heterogeneity, characterized by the rise of effector and memory cells. Autophagy, responsible for homeostatic degradation and recycling of cell cargo, is crucial for T cell differentiation. Upon ageing, autophagy is impaired, which is detrimental for the generation of memory cells retaining stemness. Interestingly, I have observed that naïve CD8+ T cells from aged mice are unable to undergo asymmetric cell division (ACD) (unpublished). ACD is a conserved mechanism to generate diversity, by endowing daughter cells with different fate determinants. As both autophagy and ACD are involved in T cell differentiation and impaired upon...
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