project . 2008 - 2009 . Closed

Identification of genetic variants underlying coronary artery disease and associated phenotypes in Indian Asians.

Wellcome Trust
  • Funder: Wellcome TrustProject code: 084723
  • Funded under: Cellular and Molecular Neuroscience Funder Contribution: 2,105,210 GBP
  • Status: Closed
  • Start Date
    01 May 2008
    End Date
    31 Oct 2009
Description
The primary objective of this study is to identify novel genetic variants underlying coronary artery disease in Indian Asians. We have already assembled a collection of Indian Asians with coronary artery disease, and population-based controls in West London. In stage one, we will carry out a Genome-Wide Association (GWA) study of 4000 coronary artery disease cases and 4000 common controls (age/sex stratified and free from coronary disease, obesity, diabetes, hypertension). This offers 86% power to detect a risk ratio of 1.2 (additive model) at MAF 20%, P<10-4. In stage two, we will replicate the ?100 top-ranking SNPs in a further 4000 Indian Asian coronary arter...
Description
The primary objective of this study is to identify novel genetic variants underlying coronary artery disease in Indian Asians. We have already assembled a collection of Indian Asians with coronary artery disease, and population-based controls in West London. In stage one, we will carry out a Genome-Wide Association (GWA) study of 4000 coronary artery disease cases and 4000 common controls (age/sex stratified and free from coronary disease, obesity, diabetes, hypertension). This offers 86% power to detect a risk ratio of 1.2 (additive model) at MAF 20%, P<10-4. In stage two, we will replicate the ?100 top-ranking SNPs in a further 4000 Indian Asian coronary arter...
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