project . 2020 - 2025 . On going

Ribosome function in plasticity and neurodevelopmental disorders

Wellcome Trust
  • Funder: Wellcome TrustProject code: 219556
  • Funded under: Cellular and Molecular Neuroscience Funder Contribution: 1,884,220 GBP
  • Status: On going
  • Start Date
    01 Feb 2020
    End Date
    01 Feb 2025
Description
Protein synthesis is essential for the strengthening and weakening of synaptic connections between neurons, and it is pathologically altered in multiple genetic models of Autism Spectrum Disorders and Intellectual Disability (ASD/ID). The identities of the mRNAs translated to sustain changes in synaptic strength are not known, nor is the mechanism linking aberrant translation to functional changes in ASD/ID. This proposal will address two key questions: (1) How does dysregulated translation lead to altered synaptic function in Fragile X Syndrome (FX), the most common monogenic cause of ASD/ID? And (2) How are specific mRNAs translated to support opposite changes...
Description
Protein synthesis is essential for the strengthening and weakening of synaptic connections between neurons, and it is pathologically altered in multiple genetic models of Autism Spectrum Disorders and Intellectual Disability (ASD/ID). The identities of the mRNAs translated to sustain changes in synaptic strength are not known, nor is the mechanism linking aberrant translation to functional changes in ASD/ID. This proposal will address two key questions: (1) How does dysregulated translation lead to altered synaptic function in Fragile X Syndrome (FX), the most common monogenic cause of ASD/ID? And (2) How are specific mRNAs translated to support opposite changes...
Any information missing or wrong?Report an Issue