project . 2021 - 2026 . On going

Molecular mechanisms determining the polarised synaptic distribution and molecular function of the retrograde endocannabinoid signalling system

Wellcome Trust
  • Funder: Wellcome TrustProject code: 220799
  • Funded under: Cellular and Molecular Neuroscience Funder Contribution: 1,104,080 GBP
  • Status: On going
  • Start Date
    01 Feb 2021
    End Date
    31 Jan 2026
Description
The endocannabinoid system (ECS) acts as a negative feedback mechanism to suppress excitatory and inhibitory synaptic transmission. This is critically important for a wide range of brain functions including appetite, pain, and cognition. Moreover, ECS dysfunction is implicated in multiple neuropathologies, and there is increasing scientific and public interest in drugs that target the ECS, including medical marijuana. The molecular organisation of the ECS is highly unusual because, in reverse to other neurotransmitter systems, endocannabinoids are released from the postsynaptic membrane to activate receptors at the presynaptic membrane. Despite its importance, r...
Description
The endocannabinoid system (ECS) acts as a negative feedback mechanism to suppress excitatory and inhibitory synaptic transmission. This is critically important for a wide range of brain functions including appetite, pain, and cognition. Moreover, ECS dysfunction is implicated in multiple neuropathologies, and there is increasing scientific and public interest in drugs that target the ECS, including medical marijuana. The molecular organisation of the ECS is highly unusual because, in reverse to other neurotransmitter systems, endocannabinoids are released from the postsynaptic membrane to activate receptors at the presynaptic membrane. Despite its importance, r...
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