Computational modelling of normal and hypertrophic cardiac electromechanics from diffusion tensor imaging and histology
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Cardiac hypertrophy is a disease in which the heart is enlarged, and is associated with an increased risk of ventricular fibrillation, an often fatal arrhythmia where the normal electrical and mechanical activity of the heart is disturbed and the heart stops pumping blood. The aim of this project is to develop computer models of the heart that can be used to investigate the causes of ventricular fibrillation during hypertrophy, and potential ways of reducing the risk of such arrhythmias occurring. The shape and structure of the heart in both normal and hypertrophic conditions will be determined using a technique known as diffusion tensor magnetic resonance imaging (DT-MRI). As little is known about how the structure of the heart varies between individuals, or from species to species, libraries of heart shape and structure will be produced that will allow comparisons to be made. Using this information, along with more data obtained using the techniques of histology and immunohistochemisrty, mathematical descriptions of the heart‘s electrical and mechanical activity will then be developed. The resulting electromechanical models will contract and change shape, something that current models do not do. These models will then be used to examine ventricular fibrillation in the hypertrophied heart.
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