By initiating a Latin American-European cooperation on innovation and entrepreneurship, the LISTO project adresses the LA universities' need to keep developing their capacities in connecting with the wider economic and social environment. The project has identified three target areas. 1.) University-industry relations; 2.) Teachings entrepreneurship skills; 3.) entrepreneurial universities. LISTO will establish an exchange of methods for matching researchers with industry R&D staff (AIMday), develop an interdisciplinary entrepreneurship skills module and train teachers in delivering an international classroom, and work on strategies for fostering an entrepreneurial spirit and innovation governance. There will be an open access ebook (in English, Spanish and Portuguese) summarizing the results and the teaching methods.