project . 2018 - 2022 . On going

MESI-STRAT

Systems Medicine of Metabolic-Signaling Networks: A New Concept for Breast Cancer Patient Stratification
Open Access mandate for Publications and Research DataOpen Access mandate for ... European Commission
  • Funder: European CommissionProject code: 754688 Call for proposal: H2020-SC1-2017-Two-Stage-RTD
  • Funded under: H2020 | RIA Overall Budget: 5,949,960 EURFunder Contribution: 5,949,960 EUR
  • Status: On going
  • Start Date
    01 Jan 2018
    End Date
    30 Sep 2022
  • Detailed project information (CORDIS)
Description
Breast cancer (BC) is a complex disease with high prevalence in the EU. 75% of the tumors are estrogen receptor-positive (ER+), and are treated with endocrine therapies (ET). MESI-STRAT will develop new concepts for knowledge-based stratification of patients into subgroups with different ET resistance mechanisms. We will establish predictive models for (1) patient stratification prior and during ET; (2) recurrence risk assessment when ending ET; (3) marker panel development to guide targeted therapies for ET-resistant patients; (4) novel ET resistance mechanism-based therapy design. The unique collection of matched BC tissue, serum, and >10 years follow-up from ...
Description
Breast cancer (BC) is a complex disease with high prevalence in the EU. 75% of the tumors are estrogen receptor-positive (ER+), and are treated with endocrine therapies (ET). MESI-STRAT will develop new concepts for knowledge-based stratification of patients into subgroups with different ET resistance mechanisms. We will establish predictive models for (1) patient stratification prior and during ET; (2) recurrence risk assessment when ending ET; (3) marker panel development to guide targeted therapies for ET-resistant patients; (4) novel ET resistance mechanism-based therapy design. The unique collection of matched BC tissue, serum, and >10 years follow-up from ...
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