project . 2019 - 2023 . On going

OXYGEN SENSING

Acute oxygen sensing and oxygen tolerance in C. elegans
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 802653 Call for proposal: ERC-2018-STG
  • Funded under: H2020 | ERC | ERC-STG Overall Budget: 1,485,000 EURFunder Contribution: 1,485,000 EUR
  • Status: On going
  • Start Date
    01 Jan 2019
    End Date
    31 Dec 2023
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
Oxygen (O2) levels can vary enormously in the environment, which induces dramatic behavioral and physiological changes to resident animals. Adaptations to O2 variations can be either acute or sustained. How animals detect and respond to the changes of O2 availability remains elusive at the molecular level. In particular, what is the precise mechanism of acute O2 sensing, what are the primary sensor for acute hypoxia, and why do neurons of various species exhibit completely different sensitivity to hypoxic challenges? The research proposed here aims at addressing these intriguing but challenging questions in the model system nematode C. elegans, which offers uniq...
Link existing DMPs with this project or start a new DMP in Argos.
Description
Oxygen (O2) levels can vary enormously in the environment, which induces dramatic behavioral and physiological changes to resident animals. Adaptations to O2 variations can be either acute or sustained. How animals detect and respond to the changes of O2 availability remains elusive at the molecular level. In particular, what is the precise mechanism of acute O2 sensing, what are the primary sensor for acute hypoxia, and why do neurons of various species exhibit completely different sensitivity to hypoxic challenges? The research proposed here aims at addressing these intriguing but challenging questions in the model system nematode C. elegans, which offers uniq...
Link existing DMPs with this project or start a new DMP in Argos.
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