project . 2016 - 2021 . On going

FORCE

Imaging the Force of Cancer
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 668039 Call for proposal: H2020-PHC-2015-two-stage
  • Funded under: H2020 | RIA Overall Budget: 7,418,120 EURFunder Contribution: 5,812,630 EUR
  • Status: On going
  • Start Date
    01 Jan 2016
    End Date
    31 Jan 2021
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
Cancer is the second leading cause of mortality in EU member states with ~90% of all cancer deaths caused by metastatic spread. Despite its significance, measuring metastatic potential as well as potential indicators of therapy efficacy remain unmet clinical challenges. Recently, it has been demonstrated in vitro, that aggressive metastatic cells pull on their surroundings suggesting that metastatic potential could be gauged by measuring the forces exert by tumours. Furthermore, many solid tumours show a significantly increased interstitial fluid pressure (IFP) which prevents the efficient uptake of therapeutic agents. As a result, a reduction in IFP is recogniz...
Description
Cancer is the second leading cause of mortality in EU member states with ~90% of all cancer deaths caused by metastatic spread. Despite its significance, measuring metastatic potential as well as potential indicators of therapy efficacy remain unmet clinical challenges. Recently, it has been demonstrated in vitro, that aggressive metastatic cells pull on their surroundings suggesting that metastatic potential could be gauged by measuring the forces exert by tumours. Furthermore, many solid tumours show a significantly increased interstitial fluid pressure (IFP) which prevents the efficient uptake of therapeutic agents. As a result, a reduction in IFP is recogniz...
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