project . 2021 - 2023 . On going

AgainstResistance

Novel Strategy to cope with Multidrug Resistant Pathogens
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 101003441 Call for proposal: H2020-WF-02-2019
  • Funded under: H2020 | MSCA-IF-EF-ST Overall Budget: 147,815 EURFunder Contribution: 147,815 EUR
  • Status: On going
  • Start Date
    01 Apr 2021
    End Date
    31 Mar 2023
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
The World Health Organization recently added Acinetobacter baumannii at the top of the priority list of emerging and critical pathogens, against which the number of effective antibiotics is alarmingly low. I propose to find novel antimicrobial targets for A. baumannii by discovering haem related systems that contribute to its survival. Bioinformatics will be used as a powerful tool to explore A. baumannii haem metabolism-related genes. The role of these genes will be tested through microbiology and biochemistry approaches, and their contribution to virulence will be analysed in host-pathogen interaction assays. This multidisciplinary research programme will boos...
Partners
Description
The World Health Organization recently added Acinetobacter baumannii at the top of the priority list of emerging and critical pathogens, against which the number of effective antibiotics is alarmingly low. I propose to find novel antimicrobial targets for A. baumannii by discovering haem related systems that contribute to its survival. Bioinformatics will be used as a powerful tool to explore A. baumannii haem metabolism-related genes. The role of these genes will be tested through microbiology and biochemistry approaches, and their contribution to virulence will be analysed in host-pathogen interaction assays. This multidisciplinary research programme will boos...
Partners
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