project . 2019 - 2024 . On going

Breakborder

Breaking borders, Functional genetic screens of structural regulatory DNA elements
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 832844 Call for proposal: ERC-2018-ADG
  • Funded under: H2020 | ERC | ERC-ADG Overall Budget: 2,497,000 EURFunder Contribution: 2,497,000 EUR
  • Status: On going
  • Start Date
    01 Sep 2019
    End Date
    31 Aug 2024
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
The human genome carries genetic information in two distinct forms: Transcribed genes and regulatory DNA elements (rDEs). rDEs control the magnitude and pattern of gene expression, and are indispensable for organismal development and cellular homeostasis. Nevertheless, while large-scale functional genetic screens greatly advanced our knowledge in studying mammalian genes, such tools to study rDEs were lacking, impeding scientific progress. Interestingly, recent advance in genome editing technologies has not only expanded the available screening toolbox to examine genes, but also opened up novel opportunities in studying rDEs. We distinguish two types of rDEs: Tr...
Partners
Description
The human genome carries genetic information in two distinct forms: Transcribed genes and regulatory DNA elements (rDEs). rDEs control the magnitude and pattern of gene expression, and are indispensable for organismal development and cellular homeostasis. Nevertheless, while large-scale functional genetic screens greatly advanced our knowledge in studying mammalian genes, such tools to study rDEs were lacking, impeding scientific progress. Interestingly, recent advance in genome editing technologies has not only expanded the available screening toolbox to examine genes, but also opened up novel opportunities in studying rDEs. We distinguish two types of rDEs: Tr...
Partners
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