project . 2022 - 2026 . Not started

ICoMICS

Individual and Collective Migration of the Immune Cellular System
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 101018587 Call for proposal: ERC-2020-ADG
  • Funded under: H2020 | ERC | ERC-ADG Overall Budget: 2,494,660 EURFunder Contribution: 2,494,660 EUR
  • Status: Not started
  • Start Date
    01 Jan 2022
    End Date
    31 Dec 2026
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
The immune system consists of a collection of cells with a high ability to migrate that work together to remove harmful foreign material from the body. Each immune cell can migrate between tissues, fulfilling specific functions in different microenvironments. However, this immune-surveillance response is not very effective in those tissues with a high non-physiological stiffness and a significant level of residual stresses, which are characteristics of solid tumors. Understanding the mechanisms that govern the cellular immune response to solid tumors is crucial to strengthen the development of novel immunotherapies. ICoMICS aims to develop a novel predictive mod...
Description
The immune system consists of a collection of cells with a high ability to migrate that work together to remove harmful foreign material from the body. Each immune cell can migrate between tissues, fulfilling specific functions in different microenvironments. However, this immune-surveillance response is not very effective in those tissues with a high non-physiological stiffness and a significant level of residual stresses, which are characteristics of solid tumors. Understanding the mechanisms that govern the cellular immune response to solid tumors is crucial to strengthen the development of novel immunotherapies. ICoMICS aims to develop a novel predictive mod...
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