Despite the tremendous socio-economic importance of Supply Chains (SCs), security officers and operators have still no easy and integrated way to protect their interconnected Critical Infrastructures (CIs) and cyber systems in the new digital era. CYRENE vision is to enhance the security, privacy, resilience, accountability and trustworthiness of SCs through the provision of a novel and dynamic Conformity Assessment Process (CAP) that evaluates the security and resilience of supply chain services, the interconnected IT infrastructures composing these services, and the individual devices that support the operations of the SCs. In order to meet its objectives, the proposed CAP is based on a collaborative, multi-level evidence-driven, Risk and Privacy Assessment approach that support, at different levels, the SCs security officers and operators to recognize, identify, model, and dynamically analyse advanced persistent threats and vulnerabilities as well as to handle daily cyber-security and privacy risks and data breaches. CYRENE will be validated in the scope of realistic scenarios/conditions comprising of real-life supply chain infrastructures and end-users. Furthermore, the project will ensure the active engagement of a large number of external stakeholders as a means of developing a wider ecosystem around the project’s results, which will set the basis for CYRENE large scale adoption and global impact.