project . 2021 - 2026 . On going

SCIMAP

Roads to memory: Studying the regulation of lymphocyte stemness by fate mapping of single T and NK cells
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 949719 Call for proposal: ERC-2020-STG
  • Funded under: H2020 | ERC | ERC-STG Overall Budget: 1,499,240 EURFunder Contribution: 1,499,240 EUR
  • Status: On going
  • Start Date
    01 Mar 2021
    End Date
    28 Feb 2026
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
Almost two decades ago it was first proposed that immunological memory may depend on stem cell-like mechanisms, enabling individual antigen-specific T and B cells to generate progeny that contains short-lived effectors as well as long-lived memory cells. To test this capacity, I have in the past developed a stringent set of single cell-based approaches, which allowed me to show that single CD8+ and CD4+ T central memory cells harbour the capacity to self-renew and generate a diverse offspring of effector cells, but also, show immense variation in executing these essential functions upon activation. Thus, even physiological immune responses to infection appear no...
Partners
Description
Almost two decades ago it was first proposed that immunological memory may depend on stem cell-like mechanisms, enabling individual antigen-specific T and B cells to generate progeny that contains short-lived effectors as well as long-lived memory cells. To test this capacity, I have in the past developed a stringent set of single cell-based approaches, which allowed me to show that single CD8+ and CD4+ T central memory cells harbour the capacity to self-renew and generate a diverse offspring of effector cells, but also, show immense variation in executing these essential functions upon activation. Thus, even physiological immune responses to infection appear no...
Partners
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