project . 2023 - 2026 . Not started

MecHA-Nano

Understanding cell-nanoparticle interactions through mechanobiology
Open Access mandate for Publications and Research DataOpen Access mandate for ... European Commission
  • Funder: European CommissionProject code: 101031744 Call for proposal: H2020-MSCA-IF-2020
  • Funded under: H2020 | MSCA-IF-GF Overall Budget: 243,964 EURFunder Contribution: 243,964 EUR
  • Status: Not started
  • Start Date
    01 Apr 2023
    End Date
    31 Mar 2026
  • Detailed project information (CORDIS)
Description
The clinical translation of nanoparticle-based therapies over the last decade has been hampered by issues such as inefficient targeting and limited therapeutic effect. This poor translational outcome calls for deeper understanding of the biomechanics of cell-nanoparticle (cell-NP) interactions. Indeed, targeting mechanosensing-activated cell pathways is suitable for tuning cell fate and readdressing its functions, as mechanosensing components control the expression of genes involved in the cell’s migration, survival and resistance to drugs. Hippo pathway appears to be one of the most promising mechanobiology pathway, as it is involved in pathological diseases an...
Partners
Description
The clinical translation of nanoparticle-based therapies over the last decade has been hampered by issues such as inefficient targeting and limited therapeutic effect. This poor translational outcome calls for deeper understanding of the biomechanics of cell-nanoparticle (cell-NP) interactions. Indeed, targeting mechanosensing-activated cell pathways is suitable for tuning cell fate and readdressing its functions, as mechanosensing components control the expression of genes involved in the cell’s migration, survival and resistance to drugs. Hippo pathway appears to be one of the most promising mechanobiology pathway, as it is involved in pathological diseases an...
Partners
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