project . 2015 - 2018 . Closed

PanCanRisk

Personalized bioinformatics for global cancer susceptibility identification and clinical management

Open Access mandate for Publications European Commission

Funder: European CommissionProject code: 635290 Call for proposal: H2020-PHC-2014-two-stage
Funded under: H2020 | RIA Overall Budget: 2,948,180 EURFunder Contribution: 2,948,180 EUR
Status: Closed
Start Date
01 Jul 2015
End Date
30 Jun 2018
Detailed project information (CORDIS)

Open Access mandate
Research Data: No

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Summary
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Description

Cancer sequencing studies have extensively investigated the landscape of somatic mutations that drive tumor development, however the importance of germline variation for cancer susceptibility has been neglected. We hypothesize that for cancer types affecting a large proportion of the population, a shared set of genes with variants of different levels of penetrance leads to the clinical phenotype. While rare germline variants are not interrogated by array-based genome-wide association studies (GWAS), these can be effectively studied by whole-genome or whole-exome sequencing. Here, we propose in-depth pan-cancer analyses, which will be implemented as part of the I...

Partners

CRG, CONSULTORIO DEXEUS, Institute Curie, EMBL, FUNDACION PUBLICA GALEGA DE MEDICINA XENOMICA, PROTEINLOGIC LIMITED

Summary

Description

Partners

CRG, CONSULTORIO DEXEUS, Institute Curie, EMBL, FUNDACION PUBLICA GALEGA DE MEDICINA XENOMICA, PROTEINLOGIC LIMITED

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