project . 2015 - 2018 . Closed

PanCanRisk

Personalized bioinformatics for global cancer susceptibility identification and clinical management
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 635290 Call for proposal: H2020-PHC-2014-two-stage
  • Funded under: H2020 | RIA Overall Budget: 2,948,180 EURFunder Contribution: 2,948,180 EUR
  • Status: Closed
  • Start Date
    01 Jul 2015
    End Date
    30 Jun 2018
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
Cancer sequencing studies have extensively investigated the landscape of somatic mutations that drive tumor development, however the importance of germline variation for cancer susceptibility has been neglected. We hypothesize that for cancer types affecting a large proportion of the population, a shared set of genes with variants of different levels of penetrance leads to the clinical phenotype. While rare germline variants are not interrogated by array-based genome-wide association studies (GWAS), these can be effectively studied by whole-genome or whole-exome sequencing. Here, we propose in-depth pan-cancer analyses, which will be implemented as part of the I...
Description
Cancer sequencing studies have extensively investigated the landscape of somatic mutations that drive tumor development, however the importance of germline variation for cancer susceptibility has been neglected. We hypothesize that for cancer types affecting a large proportion of the population, a shared set of genes with variants of different levels of penetrance leads to the clinical phenotype. While rare germline variants are not interrogated by array-based genome-wide association studies (GWAS), these can be effectively studied by whole-genome or whole-exome sequencing. Here, we propose in-depth pan-cancer analyses, which will be implemented as part of the I...
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