project . 2016 - 2021 . Closed

PATHAD

Pathways to Alzheimer's disease
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 681712 Call for proposal: ERC-2015-CoG
  • Funded under: H2020 | ERC | ERC-COG Overall Budget: 1,985,090 EURFunder Contribution: 1,985,090 EUR
  • Status: Closed
  • Start Date
    01 Dec 2016
    End Date
    30 Nov 2021
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
Critical to our understanding of Alzheimer’s disease (AD) and also to finding therapies is determining how key pathological factors interact and relate to neuronal toxicity, symptoms and disease progression. My research has focussed on amyloid beta (Aβ) moities and demonstrated that cerebrospinal fluid (CSF) Aβ42 correlates with cerebral Aβ pathology; that Aβ accumulates in the brain 10-20 years prior to onset of symptoms; and that CSF Aβ abnormalities precede CSF tau changes. However, it is increasingly clear that a simple linear model of AD aetiology and progression is inadequate. This proposal aims at developing and validating new diagnostic and prognostic bi...
Partners
Description
Critical to our understanding of Alzheimer’s disease (AD) and also to finding therapies is determining how key pathological factors interact and relate to neuronal toxicity, symptoms and disease progression. My research has focussed on amyloid beta (Aβ) moities and demonstrated that cerebrospinal fluid (CSF) Aβ42 correlates with cerebral Aβ pathology; that Aβ accumulates in the brain 10-20 years prior to onset of symptoms; and that CSF Aβ abnormalities precede CSF tau changes. However, it is increasingly clear that a simple linear model of AD aetiology and progression is inadequate. This proposal aims at developing and validating new diagnostic and prognostic bi...
Partners
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