project . 2018 - 2023 . On going

CohesinLooping

Cohesin-mediated chromosomal looping: From linear paths to 3D effects
Open Access mandate for Publications and Research DataOpen Access mandate for ... European Commission
  • Funder: European CommissionProject code: 772471 Call for proposal: ERC-2017-COG
  • Funded under: H2020 | ERC | ERC-COG Overall Budget: 1,998,380 EURFunder Contribution: 1,998,380 EUR
  • Status: On going
  • Start Date
    01 Apr 2018
    End Date
    31 Mar 2023
  • Detailed project information (CORDIS)
Description
The 3D organization of chromosomes within the nucleus is of great importance to control gene expression. The cohesin complex plays a key role in such higher-order chromosome organization by looping together regulatory elements in cis. How these often megabase-sized looped structures are formed is one of the main open questions in chromosome biology. Cohesin is a ring-shaped complex that can entrap DNA inside its lumen. However, cohesin’s default behaviour is that it only transiently entraps and then releases DNA. Our recent findings indicate that chromosomes are structured through the processive enlargement of chromatin loops, and that the duration with which co...
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Description
The 3D organization of chromosomes within the nucleus is of great importance to control gene expression. The cohesin complex plays a key role in such higher-order chromosome organization by looping together regulatory elements in cis. How these often megabase-sized looped structures are formed is one of the main open questions in chromosome biology. Cohesin is a ring-shaped complex that can entrap DNA inside its lumen. However, cohesin’s default behaviour is that it only transiently entraps and then releases DNA. Our recent findings indicate that chromosomes are structured through the processive enlargement of chromatin loops, and that the duration with which co...
Partners
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