project . 2020 - 2024 . On going

MAGNIFISCENT

mesoscale multi-mode MRI of molecular targets
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 851919 Call for proposal: ERC-2019-STG
  • Funded under: H2020 | ERC | ERC-STG Overall Budget: 1,946,250 EURFunder Contribution: 1,946,250 EUR
  • Status: On going
  • Start Date
    01 Jan 2020
    End Date
    31 Dec 2024
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
Imaging defined cells, over extended time, depends on signal strength, stability, accessibility and specificity. Whereas light-microscopy (LM) can provide these, it does not allow imaging of entire intact tissues; imaging-depths and area-size are restricted, and not easily obtained through skin and bone. Magnetic Resonance Imaging (MRI) outperforms LM in these instances; providing images of large-fields-of-view (i.e., mesoscale), at any depth, easily across bone. Nevertheless, MRI suffers from low signals, spatial resolution and cannot detect specific biological targets. To remedy these shortcomings, and significantly extend the capabilities of MRI, we propose a...
Description
Imaging defined cells, over extended time, depends on signal strength, stability, accessibility and specificity. Whereas light-microscopy (LM) can provide these, it does not allow imaging of entire intact tissues; imaging-depths and area-size are restricted, and not easily obtained through skin and bone. Magnetic Resonance Imaging (MRI) outperforms LM in these instances; providing images of large-fields-of-view (i.e., mesoscale), at any depth, easily across bone. Nevertheless, MRI suffers from low signals, spatial resolution and cannot detect specific biological targets. To remedy these shortcomings, and significantly extend the capabilities of MRI, we propose a...
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