project . 2017 - 2020 . Closed

MaRiA

Microbiota and Resolvins in Arthritis
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 746183 Call for proposal: H2020-MSCA-IF-2016
  • Funded under: H2020 | MSCA-IF-EF-RI Overall Budget: 195,455 EURFunder Contribution: 195,455 EUR
  • Status: Closed
  • Start Date
    21 Sep 2017
    End Date
    21 Feb 2020
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
The proposed work will investigate the regulation of pro-resolving lipid mediators (LM) by pathobionts and dysbiotic microbiota in rheumatoid arthritis (RA). RA is a chronic inflammatory disease with considerable socioeconomic impact. Most treatment options carry severe side effects including immunosuppression. Recent studies found associations between RA and dysbiosis of the microbiota, with the underlying mechanisms leading to this dysbiosis remaining of interest. In addition, I recently found that in both mice during pathobiont-driven inflammatory arthritis and in plasma from patients with RA the levels of a novel family of host protective LM, termed n-3 doco...
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Description
The proposed work will investigate the regulation of pro-resolving lipid mediators (LM) by pathobionts and dysbiotic microbiota in rheumatoid arthritis (RA). RA is a chronic inflammatory disease with considerable socioeconomic impact. Most treatment options carry severe side effects including immunosuppression. Recent studies found associations between RA and dysbiosis of the microbiota, with the underlying mechanisms leading to this dysbiosis remaining of interest. In addition, I recently found that in both mice during pathobiont-driven inflammatory arthritis and in plasma from patients with RA the levels of a novel family of host protective LM, termed n-3 doco...
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